Endocrine Abstracts

IntroductionSomatostatin has antiproliferative, anti-angiogenic and pro-apoptotic actions through 5 G-protein receptors (Sstr). In view of the anti-angiogenic effects of Sstrs their relationship to the distribution of vascular endothelial growth factor (VEGF) was undertaken in non-malignant Reinke's Oedema of the larynx and squamous cell carcinoma of the larynx.MethodsSix Reinke's oedema (non malignant) and 1...

IntroductionThe prognosis in head and neck cancer has remained unchanged over the last 20 years (overall 5 year survival 50-60 percent), and is adversely affected by tumour angiogenesis. The effects of the anti-proliferative and anti-angiogenic peptide somatostatin (SST) are mediated through a family 5 receptors (SSTRs 1-5), whilst the angiogenic cytokine vascular endothelial growth factor (VEGF) acts predominantly via 2 receptors: FLK and FLT. The objective of this study ...